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SETSCI - Volume 3 (2018)
ISAS2018-Winter - 2nd International Symposium on Innovative Approaches in Scientific Studies, Samsun, Turkey, Nov 30, 2018

Production of 5-FU Drug Loaded Biocomposite Materials : Drug Loading Efficiency and Characterization
Nalan Erdöl Aydın1*, Ebru Kahraman2, Gülhayat Nasün Saygılı3
1İstanbul Technical University, İstanbul, Turkey
2İstanbul Technical University, İstanbul, Turkey
3İstanbul Technical University, İstanbul, Turkey
* Corresponding author:
Published Date: 2019-01-14   |   Page (s): 1499-1502   |    232     15

ABSTRACT Hydroxyapatite/polymer composites are promising materials for drug delivery applications. Studies focusing on the
development of such composites are available in recent years, as using these materials as a carrier allows us to overcome the
side affects of toxic drugs used especially in cancer treatments and increase treatment efficiency. In this study, hydroxyapatitechitosan (HAp-CTS) biocomposites are produced in the presence of simulated body fluid (SBF) as a carrier for 5-Fluorouracil
(5-FU). 5-FU, which is widely used for the treatment of colon, rectal, breast, ovary, pancreas, stomach, brain and skin cancer,
is selected as drug. Biocomposite materials are produced by wet precipitation method at pH 7.4 and 37°C implementing
glutaraldehyde (GA) as a cross-linking agent. Drug loading process is performed during the wet precipitation. In order to
observe the effect of GA amount on drug loading efficiency, composites cross-linked with different amounts of GA are
released in deinozed water, HCl and phosphate bufffer solution (PBS). Absorbance value of the solution was obtain by Uv-vis
(Jenway 6305) spectra and calibration curve was evaluated to calculate the drug concentrations. Composites are analyzed by
X-Ray Diffraction (XRD), Thermogravimetric Analyses (TGA), Scanning Electron Microscopy (SEM) and particle size
distribution to observe morphology and structure. It is concluded that drug loaded HAp-CTS composites have a potential to be
used in drug delivery applications.  
KEYWORDS Biocomposite material, hydroxyapatite, chitosan, polymer, drug loading
REFERENCES [1] Y.Oshida, Hydroxyapatite: Synthesis and Applications, Momentum Press, LLC, New York, 2014.
[2] R. Jayakumar, M.Prabaharan, R.A.A.Muzzarelli, Chitosan for Biomaterials, Springer, 19-44, 2011.
[3] H.W. Kim, J.C. Knowles, and H.E. Kim, “Porous scaffolds of gelatinhydroxyapatite nanocomposites obtained by biomimetic approach: characterization and antibiotic drug release”, Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol.74 (2), pp. 686-698, 2005.
[4] M. Olukman, O. Şanlı, O. and E.K. Solak, “Release of anticancer drug 5-fluorouracil from different ıonically crosslinked alginate beads”, Journal of Biomaterials and Nanobiotechnology, vol.3, pp.469-479, 2012.
[5] E.Kahraman, “Research on drug release performance of hydroxyapatite-gelatin composites produced in SBF medium, Master Thesis, Istanbul Technical University, Istanbul, 2016.
[6] T.Bera, A.N.Vivek, S.K. Saraf and P.Ramachandrarao, “ Characterization of biomimetically synthesized Hap-Gel nanocomposites as bone substitute, Biomedical Materials, v.3, 2, 2008.
[7] Z. Özbaş, G. Gürdağ, “Synthesis and characterization of 5- Fluorouracil‐loaded glutaraldehyde crosslinked chitosan hydrogels, Journal of Natural and Applied Sciences, vol. 20(3), pp.460-467, 2016.
[8] S.Kumar, S. and J.Koh, “Physiochemical, optical and biological activity of chitosan-chromone derivative for biomedical applications”, International Journal of Molecular Sciences, vol.13, pp.6102-6116, 2012.
[9] R.Sahoo, S.Sahoo, and P. Lochan, “Synthesis and characterization of gelatin-chitosan nanocomposite to explore the possible use as drug delivery vehicle”, European Scientific Journal, vol.9 (18), pp.134-141, 2013.
[10] A. Misra, A.Shahiwala, Applications of Polymers in Drug Delivery, Smithers Rapra, US, Ch.2, pp.1-38, 2014.
[11] A.M. Alhalafi, “Applications of polymers in intraocular drug delivery systems”, Oman Journal of Ophthalmology, vol. 10(1), pp.3-8, 2017.
[12] R.Gouda, H.Baishya and Z. Qing, Zhao, “Application of mathematical models in drug release kinetics of carbidopa and levodopa ER tablets”, Journal of Developing Drugs, vol. 6(2), 2017.
[13] M.C. Chang, W.H.Douglas and J. Tanaka, “Organic-inorganic interaction and the growth mechanism of hydroxyapatite crystals in gelatin matrices between 37 and 80C”, Journal of Materials Science, vol.17, pp.387-396, 2006.
[14] D.C.Wu, C.R.Cammarata, H.J.Park, B.T. Rhodes and C.M. Ofner, “Preparation, drug release, and cell growth inhibition of a gelatin: Doxorubicin conjugate”, Pharmaceutical Research, vol.30, pp.2087-2096, 2013.
[15] Y.Lin, Y.Li and C.P. Ooi, “5-Fluorouracil Encapsulated HA/PLGA Composite Microspheres for Cancer Therapy”, Journal of Materials Science: Materials in Medicine, vol.23, pp.2453–2460, 2012.
[16] G.O. Elhassan, “Design and evaluation of controlled release matrix tablet of aspirin by using hydrophobic polymer”, International Journal of Pharmaceutical Research & Allied Sciences, vol.6(4), pp.32-41, 2017.

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