Open Access
Evaluation of choroidal thickness in patients with papulopustular rosacea
Tayfun Şahin1*
1Hitit University, Çorum, Turkey
* Corresponding author:

Presented at the 4th International Symposium on Innovative Approaches in Health and Sports Sciences (ISAS WINTER-2019 (HSS)), Samsun, Turkey, Nov 22, 2019

SETSCI Conference Proceedings, 2019, 12, Page (s): 17-19 ,

Published Date: 23 December 2019    | 726     42


To evaluate and compare choroidal thickness in patients with PPR (papulopustular rosacea) and healthy controls. Methods: In this prospective, cross-sectional study, thirty eyes of 30 patients with PPR and 30 eyes of 30 age- and sex-matched healthy subjects were enrolled. The choroidal thickness measurements of the subjects were obtained using spectral domain optical coherence tomography (Heidelberg Spectralis OCT). Choroidal thickness (CT) at three defined points (subfoveal [sfCT] ,1000 μm  [N1000] and  1000 μm [T1000] from the centre of the fovea) were measured. Results: Choroidal thicknesses at subfoveal region were 352,02 ± 77,94 μm and 345,97 ± 83,01 μm; at 1000 μm nasally were 322,50 ± 72,32 μm   and 313,65±80,17 μm; at 1000 μm temporally 325,24 ± 71,01 μm and 309,24 ± 66,89 μm in the PPR and control groups, respectively . Choroidal thicknesses were thicker at all measurement location but this was not statistically significant (p>0.05). Conclusion: The results of this study demonstrated that choroidal thickness increases in patients with PPR. These choroidal changes might be related to the elevating blood cytokine levels.

Keywords - Choroidal thicknesses, optical coherence tomography, papulopustular rosacea


1. Spoendlin J, Voegel JJ, Jick SS, Meier CR. A study on the epidemiology of rosacea in the U.K. Br J Dermatol. 2012;167:598-605.
2. Spoendlin J, Karatas G, Furlano RI, Jick SS ve ark. Rosacea in Patients with Ulcerative Colitis and Crohn's Disease: A Population-based Case-control Study. Inflamm Bowel Dis. 2016;22:680-687.
3. Rainer BM, Fischer AH, Luz Felipe da Silva D, Kang S ve ark. Rosacea is associated with chronic systemic diseases in a skin severity-dependent manner: results of a case-control study. J Am Acad Dermatol 2015;73:604-608.
4. Holmes AD, Spoendlin J, Chien AL, Baldwin H ve ark. Evidence-based update on rosacea comorbidities and their common physiologic pathways. J Am Acad Dermatol 2018;78:156-166.
5. Casas C, Paul C, Lahfa M, Livideanu B, Lejeune O, Alvarez-Georges S, et al. Quantification of Demodex folliculorum by PCR in rosacea and its relationship to skin innate immune activation. Exp Dermatol. 2012;21(12):906–910.
6. Wilkin J, Dahl M, Detmar M, Drake L ve ark. Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol. 2002;46:584-587.
7. Gerber PA, Buhren BA, Steinhoff M, Homey B. Rosacea: The cytokine and chemokine network. J Investig Dermatol Symp Proc 2011;15:40-47.
8. Milikan LE. Rosacea as an inflammatory disorder: a unifying theory? Cutis. 2004;73 (suppl 1):5–8.
9. Sinikumpu SP, Huilaja L, Auvinen J, Jokelainen J ve ark. The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966. Acta Derm Venereol 2018;98:65-69.
10. Turkcu FM, Sahin A, Yuksel H, et al. Evaluation of choroidal thickness in psoriasis using optical coherence tomography. Int Ophthalmol. 2016;36(6):851-854.
11. Kilic R, Kurt A, Acer E, Oktem C, Kocamis O. Choroidal thickness in psoriasis. Int Ophthalmol. 2017;37(1):173-177.
12. Chung YR, Cho EH, Jang S, Lee SY, Lee ES, Lee K. Choroidal thickness indicates subclinical ocular and systemic inflammation in eyes with behcet disease without active inflammation. Korean J Ophthalmol. 2018;32(4):290-295.
13. Buhl T, Sulk M, Nowak P, Buddenkotte J ve ark. Molecular and Morphological Characterization of Inflammatory Infiltrate in Rosacea Reveals Activation of Th1/Th17 Pathways. J Invest Dermatol 2015;135:2198-2208.
14. Holmes AD, Steinhoff M. Integrative concepts of rosacea pathophysiology, clinical presentation and new therapeutics. Exp Dermatol 2017;26:659-667.

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