Open Access
The Effects of Resveratrol Supplementation on Bone Tissue SIRT1 levels in old Female Rats with Diabetic
Kübra Kıyar1, Ömer Ünal2, Saltuk Buğra Baltacı3, Nilüfer Akgün Ünal4, Rasim Mogulkoc5, Abdülkerim Kasım Baltacı6*
1Selcuk University, Konya, Turkey
2Selcuk University, Konya, Turkey
3Selcuk University, Konya, Turkey
4Selcuk University, Konya, Turkey
5Selcuk University, Konya, Turkey
6Selcuk University, Konya, Turkey
* Corresponding author:

Presented at the 4th International Symposium on Innovative Approaches in Health and Sports Sciences (ISAS WINTER-2019 (HSS)), Samsun, Turkey, Nov 22, 2019

SETSCI Conference Proceedings, 2019, 12, Page (s): 24-25 ,

Published Date: 23 December 2019    | 770     35


The aim of this study was to investigate how resveratrol administration  diabetic elderly female  rats affects the levels of bone tissue SIRT1. The study was performed on female aged rats (16 months old) who were provided by The Experimental Medicine Research and Application Center of Selçuk University.  A total of 24 elderly female rats were divided into 4 groups: Group 1. Control, Group 2. Control + Resveratrol, Group 3. Diabetes, Group 4. Diabetes + Resveratrol. In order to induce diabetes, the animals were intraperitoneally (IP) injected with 40 mg/kg streptozotocin (STZ). The animals were supplemented with 5 mg/kg/day resveratrol IP for 4 weeks.  At the end of the study, SIRT1 protein gene expression  were determined by PCR, on bone tissue samples obtained from the  animals  sacrificed  under general anesthesia. In our study, the highest bone tissue SIRT1 expression values were obtained in the diabetes + resveratrol group (G4) and the lowest bone SIRT 1 levels were found in the diabetes group (G3). Our results suggest that resveratrol supplementation increases bone SIRT1 expression in diabetic elderly female rats

Keywords - old female rats, diabetes mellitus, resveratrol supplementation, SIRT1, bone tissue


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