{
    "article_id": 606,
    "public_id": "467607c4-11f3-4eca-a6f4-9ed1f9b4db6e",
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    "source_identifier": "5:256",
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    "title": "Antioksidanların Antioksidanı Alfa Lipoik Asit (ALA)",
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    "abstract": "Serbest oksijen radikali (SOR), organizmada metabolik reaksiyonlar sırasında sürekli olarak üretilen ve endojen antioksidan mekanizmalarla etkisizleştirilmeye çalışılan oksijen metabolitleridir. Enfeksiyöz ajanlara karşı savunma ve hücresel sinyal sistemlerinde görev alması gibi yararlı\r\netkilerinin yanında, oksidatif stresi arttırarak hücresel lipidlere, proteinlere ve DNA’ya zarar vermesi gibi zararlı etkileri mevcuttur (1). Travma, iskemi veya enfeksiyon nedenlere bağlı oluşabilecek doku hasarı sonrası oluşan SOR vücuttaki oksidatif stresi arttırır (2). SOR ile hızlı reaksiyonlara girerek oksidasyon/peroksidasyon ilerlemesini önleyen ve/veya etksizileştiren maddelere antioksidanlar denir (3). Antioksidanların bu reaksiyonları engelleyerek doku  hasarını azaltmasına veya engellemesine ise antioksidan savunma sistemi denir (4). Zincir kırma reaksiyonlarının her basamağında hidroperoksit oluşması, ortamdaki ürünler ve hasarın tamamiyle engellenememesi nedeniyle oksidasyon reaksiyonları ve SOR tamamen yok edilemez (5). Oksidatif\r\nstrese bağlı artan SOR veya antioksidan yetersizliği sonucunda bozulan hücresel metabolizma, moleküler yıkılma ve doku hasarını oluşur (6). Antioksidan Savunma: Radikal metabolit üretiminin engellenmesi, üretilmiş radikallerin temizlenmesi, hücre hasarının onarılması, sekonder radikal reaksiyonların\r\nengellenmesi,endojen antioksidan kapasitenin arttırılması olarak beş değişik yolağın tamamıdır (7).  ",
    "language": "tr",
    "english_title": "Antioxidant of Antioxidants: Alpha Lipoic Acid (ALA)",
    "english_abstract": "Free oxygen radicals (SORs) are oxygen metabolites continuously produced during metabolic reactions in the organism and are attempted to be neutralized by endogenous antioxidant mechanisms. In addition to beneficial effects such as defense against infectious agents and involvement in cellular signaling systems, they also have harmful effects such as increasing oxidative stress and damaging cellular lipids, proteins, and DNA (1). SORs formed after tissue damage caused by trauma, ischemia, or infection increase oxidative stress in the body (2). Substances that react rapidly with SORs and prevent and/or neutralize the progression of oxidation/peroxidation are called antioxidants (3). The reduction or prevention of tissue damage by antioxidants by inhibiting these reactions is called the antioxidant defense system (4). Because hydroperoxides are formed at each step of chain-breaking reactions, and the products and damage in the environment cannot be completely prevented, oxidation reactions and SORs cannot be completely eliminated (5). Oxidative stress-related increased SOR or antioxidant deficiency results in impaired cellular metabolism, molecular degradation, and tissue damage (6). Antioxidant Defense: It is the sum of five different pathways: inhibition of radical metabolite production, scavenging of produced radicals, repair of cell damage, inhibition of secondary radical reactions, and increasing endogenous antioxidant capacity (7).",
    "doi": null,
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            "language": "en",
            "title": "Antioxidant of Antioxidants: Alpha Lipoic Acid (ALA)",
            "abstract": "Free oxygen radicals (SORs) are oxygen metabolites continuously produced during metabolic reactions in the organism and are attempted to be neutralized by endogenous antioxidant mechanisms. In addition to beneficial effects such as defense against infectious agents and involvement in cellular signaling systems, they also have harmful effects such as increasing oxidative stress and damaging cellular lipids, proteins, and DNA (1). SORs formed after tissue damage caused by trauma, ischemia, or infection increase oxidative stress in the body (2). Substances that react rapidly with SORs and prevent and/or neutralize the progression of oxidation/peroxidation are called antioxidants (3). The reduction or prevention of tissue damage by antioxidants by inhibiting these reactions is called the antioxidant defense system (4). Because hydroperoxides are formed at each step of chain-breaking reactions, and the products and damage in the environment cannot be completely prevented, oxidation reactions and SORs cannot be completely eliminated (5). Oxidative stress-related increased SOR or antioxidant deficiency results in impaired cellular metabolism, molecular degradation, and tissue damage (6). Antioxidant Defense: It is the sum of five different pathways: inhibition of radical metabolite production, scavenging of produced radicals, repair of cell damage, inhibition of secondary radical reactions, and increasing endogenous antioxidant capacity (7).",
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    "published_date": "2018-06-23",
    "published_year": "2018",
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    "volume": "2",
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    "page_first": "388",
    "page_last": "390",
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        "short_name": "ISAS 2018",
        "full_title": "Ist International Symposium on Innovative Approaches in Scientific Studies",
        "name": "Ist International Symposium on Innovative Approaches in Scientific Studies",
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        "title": "Ist International Symposium on Innovative Approaches in Scientific Studies",
        "series_title": "Setsci conference indexing system",
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        "slug": "setsci-volume-2-2018-legacy-5",
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        "url": "https://www.set-science.com/p/setsci-volume-2-2018-legacy-5"
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        "year": "2018"
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    "history": {
        "published": "2018-06-23"
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}