{ "article_id": 490, "public_id": "5565399b-ae03-4bdc-9718-697e8d9feebc", "internal_identifier": null, "source_identifier": "5:136", "status": "published", "type": "research_article", "title": "A Functionalized-Gold Nanoparticles Based Optical Nanosensor for Biomolecule Detection", "title_secondary": null, "abstract": "Over the past decade, gold nanoparticles (AuNPs) have stimulated great interest in various types of sensors because\r\nthey possess many attractive properties such as optical, electronic and chemical features [1]. In order to gain more intrinsic\r\nproperties and much more selectivity, the surface of AuNPs is functionalized by selective groups/macromolecules. In this regard,\r\ncyclodextrins (CD) are known as capable module units to host various molecules. Taking advantage of AuNPs and β-CD, we\r\nherein report an optical nanosensor for sensing of amino acid enantiomers. To this aim, we synthesized β-cyclodextrin\r\nfunctionalized gold nanoparticles (βCD@AuNPs) by reduction of HAuCl4 in the presence of β-CD. Within this respect, the\r\nprepared solutions of β-CD and HAuCl4 were mixed at room temperature to give a clear solution. Then the resultant was heated\r\nat 100 °C and stirred for 4 h leading to the formation of Au nanoparticles. The color turned to red wine proving the formation of\r\nAuNPs [2]. To prove the settlement of β-CDs on AuNPs, the structural characterization of β-CD@AuNPs was performed by FTIR and UV-Vis spectroscopy, and compared to bare β-CD and AuNPs. The sensor performance was evaluated by following the\r\ncolour change in the presence of the tested bioactive molecules (herein, proline, phenylalanine, leucine, thereonine, valine,\r\nglutamine, tartaric acid, serine, mandelic acid, methionine, alanine, cystine, tryptophan, tyrosine, histidine, arginine, lysine were\r\ntested as model analytes) in solution. The results show that β-CD@AuNPs exhibits different affinity and this nanosensor can\r\npave the way for selective detection of the other biomolecules.  ", "language": "en", "english_title": null, "english_abstract": null, "doi": null, "doi_url": null, "resource_url": "https://www.set-science.com/a/5565399b-ae03-4bdc-9718-697e8d9feebc", "pdf_url": "https://www.set-science.com/a/5565399b-ae03-4bdc-9718-697e8d9feebc/pdf", "og_image": "https://www.set-science.com/assets/img/og-card-v2.png", "authors": [ { "public_id": "542687e7-cc59-4f08-a7d2-405c4601f813", "given": "Nisa", "family": "Bekar", "full": "Nisa Bekar", "literal": null, "orcid": null, "orcid_url": null, "email": "bekarnisa@gmail.com", "corresponding": true, "sequence": "first", "affiliations": [ { "name": "Department of Nanoscience and Nanoengineering, Institute of Science, Necmettin Erbakan University ", "department": null, "country": null, "country_code": null, "ror": null, "ror_url": null } ] }, { "public_id": "0d6d3e7d-be37-4c8f-8bb4-3c2b9c211bf3", "given": "Kübra", "family": "Soğancı", "full": "Kübra Soğancı", "literal": null, "orcid": null, "orcid_url": null, "email": "kbrasgnc_92@hotmail.com", "corresponding": false, "sequence": "additional", "affiliations": [ { "name": "Department of Nanoscience and Nanoengineering, Institute of Science, Necmettin Erbakan University", "department": null, "country": null, "country_code": null, "ror": null, "ror_url": null } ] }, { "public_id": "e2acae7e-91bb-497c-a694-efa39884102d", "given": "İlker", "family": "Akın", "full": "İlker Akın", "literal": null, "orcid": null, "orcid_url": null, "email": "ilker0997@gmail.com", "corresponding": false, "sequence": "additional", "affiliations": [ { "name": "Department of Biotechnology, Faculty of Science, Necmettin Erbakan University ", "department": null, "country": null, "country_code": null, "ror": null, "ror_url": null } ] }, { "public_id": "6771eae2-4315-427b-bf79-9cadd944a3da", "given": "Haluk", "family": "Bingöl", "full": "Haluk Bingöl", "literal": null, "orcid": null, "orcid_url": null, "email": "halukbingol@gmail.com", "corresponding": false, "sequence": "additional", "affiliations": [ { "name": "KimyaÖğretmenliği Anabilim Dalı, Ahmet Keleşoğlu Eğitim Fakültesi, Necmettin Erbakan Üniversitesi ", "department": null, "country": null, "country_code": null, "ror": null, "ror_url": null } ] }, { "public_id": "26f90626-9c35-477f-b001-8c764f4724dc", "given": "Erhan", "family": "Zor", "full": "Erhan Zor", "literal": null, "orcid": null, "orcid_url": null, "email": "zorerhan@gmail.com", "corresponding": false, "sequence": "additional", "affiliations": [ { "name": "Fen Bilgisi Öğretmenliği Anabilim Dalı, Ahmet Keleşoğlu Eğitim Fakültesi, Necmettin Erbakan Üniversitesi ", "department": null, "country": null, "country_code": null, "ror": null, "ror_url": null } ] } ], "keywords": [ "Gold nanoparticles, nanosensor, amino acid enantiomers" ], "translations": [ { "language": "en", "title": "A Functionalized-Gold Nanoparticles Based Optical Nanosensor for Biomolecule Detection", "abstract": "Over the past decade, gold nanoparticles (AuNPs) have stimulated great interest in various types of sensors because\r\nthey possess many attractive properties such as optical, electronic and chemical features [1]. In order to gain more intrinsic\r\nproperties and much more selectivity, the surface of AuNPs is functionalized by selective groups/macromolecules. In this regard,\r\ncyclodextrins (CD) are known as capable module units to host various molecules. Taking advantage of AuNPs and β-CD, we\r\nherein report an optical nanosensor for sensing of amino acid enantiomers. To this aim, we synthesized β-cyclodextrin\r\nfunctionalized gold nanoparticles (βCD@AuNPs) by reduction of HAuCl4 in the presence of β-CD. Within this respect, the\r\nprepared solutions of β-CD and HAuCl4 were mixed at room temperature to give a clear solution. Then the resultant was heated\r\nat 100 °C and stirred for 4 h leading to the formation of Au nanoparticles. The color turned to red wine proving the formation of\r\nAuNPs [2]. To prove the settlement of β-CDs on AuNPs, the structural characterization of β-CD@AuNPs was performed by FTIR and UV-Vis spectroscopy, and compared to bare β-CD and AuNPs. The sensor performance was evaluated by following the\r\ncolour change in the presence of the tested bioactive molecules (herein, proline, phenylalanine, leucine, thereonine, valine,\r\nglutamine, tartaric acid, serine, mandelic acid, methionine, alanine, cystine, tryptophan, tyrosine, histidine, arginine, lysine were\r\ntested as model analytes) in solution. The results show that β-CD@AuNPs exhibits different affinity and this nanosensor can\r\npave the way for selective detection of the other biomolecules.  \r\n", "keywords": [ "Gold nanoparticles, nanosensor, amino acid enantiomers" ] } ], "subjects": [], "subject_names": [], "published_date": "2018-06-23", "published_year": "2018", "received_date": null, "accepted_date": null, "volume": "2", "issue": null, "page_first": "146", "page_last": "146", "article_number": null, "conference": { "short_name": "ISAS 2018", "full_title": "Ist International Symposium on Innovative Approaches in Scientific Studies", "name": "Ist International Symposium on Innovative Approaches in Scientific Studies", "acronym": "ISAS 2018", "location": "Kemer-Antalya, Türkiye", "start_date": "2018-04-11", "end_date": null, "public_id": "1d94fec9-c4fe-4034-9157-0b205eef4e56" }, "proceedings": { "title": "Ist International Symposium on Innovative Approaches in Scientific Studies", "series_title": "Setsci conference indexing system", "publisher": "SET Technology", "isbn": null, "eisbn": null, "issn": "2618-6446", "eissn": null, "doi": null, "doi_prefix": null, "slug": "setsci-volume-2-2018-legacy-5", "public_id": "03da7b1c-cb6e-4f3b-aee4-ac41ee60fd75", "url": "https://www.set-science.com/p/setsci-volume-2-2018-legacy-5" }, "license": { "name": "CC BY 4.0", "url": "https://creativecommons.org/licenses/by/4.0/", "code": "CC-BY-4.0", "open_access": true }, "copyright": { "holder": "SET Technology", "year": "2018" }, "funding_statement": null, "funders": [], "references": [ { "order": 1, "raw": "Zor, E. and Bekar, N., Biosens. Bioelectron. 2017, 91, 211–216.", "doi": null, "title": null, "authors": null, "source": null, "year": null, "volume": null, "pages": null }, { "order": 2, "raw": "Huang, T. et al., J. Phys. Chem. C 2009, 113, 13636–13642.", "doi": null, "title": null, "authors": null, "source": null, "year": null, "volume": null, "pages": null } ], "statements": { "acknowledgements": null, "conflict_of_interest": null, "data_availability": null, "ai_disclosure": null }, "credit": [], "history": { "published": "2018-06-23" } }