{
    "article_id": 1207,
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    "title": "Alzheimer's and Huntington as Neurodegenerative Diseases",
    "title_secondary": null,
    "abstract": "Neurodegenerative diseases (NDD) are a group of diseases characterized by progressive loss of neuron function and structural deterioration. This may be due to damage at birth, as well as by the effect of genetic factors and aging, or as a combination of these. Of these diseases, the more common Alzheimer's disease (AD) generally presents at an advanced age, while Huntington disease (HD) tends to occur at an early age. AD is the most common cause of dementia in the elderly. AD is the most common cause of dementia in the elderly, is a progressive neurodegenerative disease that causes loss of cognitive function and ultimately death. The pathology of AD is mainly composed of senile plaques and neurofibrillary tangles (NFT). HD, one of the neurodegenerative diseases of the central nervous system, is a trinucleotide repeat disorder. HD is characterized by involuntary movements called Korea, memory loss, impaired motor coordination, and accompanying psychiatric symptoms. In this study, the most common neurodegenerative disease (Alzheimer's and Huntington disease) will be discussed and experimental models designed to investigate the pathogenesis, diagnosis and treatment options of neurodegenerative diseases will be discussed.  ",
    "language": "en",
    "english_title": null,
    "english_abstract": null,
    "doi": "10.36287/setsci.4.6.030",
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        {
            "public_id": "fae188c5-6737-4189-a7d0-af9edbae30f8",
            "given": "Tuğçe",
            "family": "Karaduman",
            "full": "Tuğçe Karaduman",
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            "orcid": null,
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            "email": "tugcekaraduman48@gmail.com",
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                {
                    "name": "Aksaray University",
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        {
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            "given": "Habibe",
            "family": "Kutuk",
            "full": "Habibe Kutuk",
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            "email": "habibekutuk97@gmail.com",
            "corresponding": true,
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            "affiliations": [
                {
                    "name": "Aksaray University",
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    ],
    "keywords": [
        "Neurodegenerative diseases, Alzheimer’s, Huntington, experimental models"
    ],
    "translations": [
        {
            "language": "en",
            "title": "Alzheimer's and Huntington as Neurodegenerative Diseases",
            "abstract": "Neurodegenerative diseases (NDD) are a group of diseases characterized by progressive loss of neuron function and structural deterioration. This may be due to damage at birth, as well as by the effect of genetic factors and aging, or as a combination of these. Of these diseases, the more common Alzheimer's disease (AD) generally presents at an advanced age, while Huntington disease (HD) tends to occur at an early age. AD is the most common cause of dementia in the elderly. AD is the most common cause of dementia in the elderly, is a progressive neurodegenerative disease that causes loss of cognitive function and ultimately death. The pathology of AD is mainly composed of senile plaques and neurofibrillary tangles (NFT). HD, one of the neurodegenerative diseases of the central nervous system, is a trinucleotide repeat disorder. HD is characterized by involuntary movements called Korea, memory loss, impaired motor coordination, and accompanying psychiatric symptoms. In this study, the most common neurodegenerative disease (Alzheimer's and Huntington disease) will be discussed and experimental models designed to investigate the pathogenesis, diagnosis and treatment options of neurodegenerative diseases will be discussed.  ",
            "keywords": [
                "Neurodegenerative diseases, Alzheimer’s, Huntington, experimental models"
            ]
        }
    ],
    "subjects": [],
    "subject_names": [],
    "published_date": "2019-12-22",
    "published_year": "2019",
    "received_date": null,
    "accepted_date": null,
    "volume": "9",
    "issue": null,
    "page_first": "101",
    "page_last": "103",
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    "conference": {
        "short_name": "ISAS WINTER-2019 (ENS)",
        "full_title": "4th International Symposium on Innovative Approaches in Engineering and Natural Sciences",
        "name": "4th International Symposium on Innovative Approaches in Engineering and Natural Sciences",
        "acronym": "ISAS WINTER-2019 (ENS)",
        "location": "Samsun, Türkiye",
        "start_date": "2019-11-22",
        "end_date": null,
        "public_id": "ede2435c-3820-4bef-84a9-59e7d8de9d60"
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    "proceedings": {
        "title": "4th International Symposium on Innovative Approaches in Engineering and Natural Sciences",
        "series_title": "SETSCI Conference Proceedings",
        "publisher": "SET Technology",
        "isbn": "978-605-81988-8-3",
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        "eissn": "2687-5527",
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        "doi_prefix": "10.36287",
        "slug": "setsci-volume-9-2019-legacy-84",
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        "url": "https://www.set-science.com/p/setsci-volume-9-2019-legacy-84"
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        "name": "CC BY 4.0",
        "url": "https://creativecommons.org/licenses/by/4.0/",
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    "copyright": {
        "holder": "SET Technology",
        "year": "2019"
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    "references": [
        {
            "order": 1,
            "raw": "Shamim IA. Neurodegenerative Diseases. New York: Springer; 2012.",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        },
        {
            "order": 2,
            "raw": "Avila J, Lucas J, Hernandes F. Animal Models for Neurodegenerative Disease. Cambridge: The Royal Society of Chemistry; 2011.",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        },
        {
            "order": 3,
            "raw": "Hardiman O, Doherty CP, Elamin M, Bede P. Neurodegenerative Disorders. Switzerland: Springer International Publishing; 2016.",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        },
        {
            "order": 4,
            "raw": "Cankurtaran M, Arıo¤ul S. Alzheimer hastalı¤ı ve demans tedavisinde yenilikler. Türkiye Tıp Dergisi 2002; 9:128-36.",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        },
        {
            "order": 5,
            "raw": "Perl DP. Neuropathology of Alzheimer's Disease. Mt Sinai J Med 2010;77:32-42",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        },
        {
            "order": 6,
            "raw": "Şahin Ş. Deneysel Alzheimer Hastalı¤ı Modelleri. Turkiye Klinikleri Journal of Neurology Special Topics 2012;5:102-6.",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        },
        {
            "order": 7,
            "raw": "Puzzo D, Gulisano W, Palmeri A, Arancio O. Rodent models for Alzheimer's disease drug discovery. Expert Opin Drug Discov 2015;10:703-11.",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        },
        {
            "order": 8,
            "raw": "Chesselet MF, Carmichael ST. Animal models of neurological disorders. Neurotherapeutics 2012;9:241-4.",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        },
        {
            "order": 9,
            "raw": "Bajo R, Pusil S, López ME, Canuet L, Pereda E, Osipova D, et al. Scopolamine effects on functional brain connectivity: a pharmacological model of Alzheimer's disease. Sci Rep 2015;5:9748.",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        },
        {
            "order": 10,
            "raw": "McGowan E, Eriksen J, Hutton M. A decade of modeling Alzheimer's disease in transgenic mice. Trends Genet 2006;22:281-9.",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        },
        {
            "order": 11,
            "raw": "Ersoy N, Başak AN. Molecular Biology of Huntington's Disease. Turk J Neurol 2005;11:27-44.",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        },
        {
            "order": 12,
            "raw": "Pouladi MA, Morton AJ, Hayden MR. Choosing an animal model for the study of Huntington's disease. Nature Reviews. Neuroscience 2013;14:708–21.",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        },
        {
            "order": 13,
            "raw": "Li JY, Popovic N, Brundin P. The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies. NeuroRx 2005;2:447–64.",
            "doi": null,
            "title": null,
            "authors": null,
            "source": null,
            "year": null,
            "volume": null,
            "pages": null
        }
    ],
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        "published": "2019-12-22"
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