{ "article_id": 1403, "public_id": "9b8bf734-8d83-44fc-8cdb-ec9d58d644a4", "internal_identifier": null, "source_identifier": "87:62", "status": "published", "type": "research_article", "title": "Çocuklarda İdrar Kültürlerinden İzole Edilen Escherichia coli Suşlarında Antibiyotik Direnci", "title_secondary": null, "abstract": "Antibiyotik direncinin artışı güncel endişe kaynaklarından biri olmuştur, bu yüzden çoğu enfeksiyonun tedavisi zorlaşmaktadır. Bu çalışmanın amacı çocukluk çağı idrar yolu enfeksiyonlarında (İYE) en sık karşılaşılan bakterial ajan etkeni Esherichia coli’ye karşı antibiyotik direnç durumunu araştırmaktır.       Bu araştırmada 7 yıllık bir süre içinde Gaziosmanpaşa Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı’nda İYE tanısıyla izlenen çocuklara ait idrar kültürlerinde üreme saptanan 1663 idrar örneğine ait veriler incelendi. İdrar toplama yöntemi olarak büyük çocuklarda orta akım idrarı, 2 yaş altı çocuklarda steril idrar torbası yöntemi uygulandı. Olguların 1376’si kız (%83), 287’si erkekti (%17). Hastaların 402 (%24)’si 2 yaş altında, 347 (%21)’si 2-5 yaş arasında, 717(%43)’si 6-11 yaş aralığında ve 197 (%12)’si 12-18 yaş aralığında idi. En yüksek direnç oranları trimetoprim/ sulfametoksazol için %48, ampisilin için %66, amoksisilin-klavülanik asit için %46 ve ampisilin / sülbaktam için %59 idi, en düşük direncin imipenem (%0,1), meropenem (%0,1), fosfomisin (%0,6), nitrofurontoin (%4) ve amikasin’e (%3) karşı gelişmiş olduğu görüldü.       İncelediğimiz çocuklarda, en yüksek direnç trimetoprim/sulfametoksazol, ampisilin, ampisilin/sulbaktam ve amoksisilin-klavunik asite karşı vardı. En az direnç ise amikasin, nitrofrontoin, fosfomisin ve karbapenemlere karşı saptandı.", "language": "tr", "english_title": "Antibiotic resistance rates to Escherichia coli isolated from urine cultures in children", "english_abstract": "The development of high antibiotic resistance has been one of the current concerns, so treatment of various infections has become even more difficult. The aim of this study was to investigate the antibiotic resistance to Esherichia coli, the most common bacterial agent in childhood urinary tract infections (UTI). In this study, data of 1663 urine cultures of children diagnosed with UTI in the Department of Pediatrics, Gaziosmanpaşa University, were examined. Urine collection was performed by mid-flow urine in older children and sterile bag method in children below 2 years’ old. Of the cases, 1376 were female (83%) and 287 were male (17%). 402 (24%) of the cases were under 2 years of age, 347 (21%) were between the ages of 2-5, 717 (43%) were between the ages of 6-11 and 197 (12%) were between the ages of 12-18. The highest resistance rates were 48% for trimetoprim/sulfamethoxazole, 66% for ampicillin, 46% for amoxicillin-clavunic acid and 59% for ampicillin/sulbactam and the lowest resistance were found against imipenem (0.1%), meropenem (0.1%), fosfomycin (0.6%), nitrofurontoin (4%) and amikacin (3%). In conclusion, the highest resistance rates to E.coli in children were determined against trimethoprim sulfamethoxazole, ampicillin, ampicillin/sulbactam and amoxicillin-clavunic acid. The lowest resistance rates were determined against amikacin, nitrofrontoin, fosfomycin and carbapenems.", "doi": "10.36287/setsci.4.9.062", "doi_url": "https://doi.org/10.36287/setsci.4.9.062", "resource_url": "https://www.set-science.com/a/9b8bf734-8d83-44fc-8cdb-ec9d58d644a4", "pdf_url": "https://www.set-science.com/a/9b8bf734-8d83-44fc-8cdb-ec9d58d644a4/pdf", "og_image": "https://www.set-science.com/assets/img/og-card-v2.png", "authors": [ { "public_id": "ef32dcc4-928b-464e-a294-78e22542f6c5", "given": "Erhan", "family": "Karaaslan", "full": "Erhan Karaaslan", "literal": null, "orcid": null, "orcid_url": null, "email": "drekaraaslan@gmail.com", "corresponding": true, "sequence": "first", "affiliations": [ { "name": "Tokat GaziosmanPaşa University", "department": null, "country": null, "country_code": null, "ror": null, "ror_url": null } ] }, { "public_id": "56388759-43ff-4a4c-9bd0-a9886194bcf2", "given": "Meryem", "family": "Çetin", "full": "Meryem Çetin", "literal": null, "orcid": null, "orcid_url": null, "email": "meryemcetin55@yahoo.com", "corresponding": false, "sequence": "additional", "affiliations": [ { "name": "Tokat GaziosmanPaşa University", "department": null, "country": null, "country_code": null, "ror": null, "ror_url": null } ] } ], "keywords": [], "translations": [ { "language": "en", "title": "Antibiotic resistance rates to Escherichia coli isolated from urine cultures in children", "abstract": "The development of high antibiotic resistance has been one of the current concerns, so treatment of various infections has become even more difficult. The aim of this study was to investigate the antibiotic resistance to Esherichia coli, the most common bacterial agent in childhood urinary tract infections (UTI). In this study, data of 1663 urine cultures of children diagnosed with UTI in the Department of Pediatrics, Gaziosmanpaşa University, were examined. Urine collection was performed by mid-flow urine in older children and sterile bag method in children below 2 years’ old. Of the cases, 1376 were female (83%) and 287 were male (17%). 402 (24%) of the cases were under 2 years of age, 347 (21%) were between the ages of 2-5, 717 (43%) were between the ages of 6-11 and 197 (12%) were between the ages of 12-18. The highest resistance rates were 48% for trimetoprim/sulfamethoxazole, 66% for ampicillin, 46% for amoxicillin-clavunic acid and 59% for ampicillin/sulbactam and the lowest resistance were found against imipenem (0.1%), meropenem (0.1%), fosfomycin (0.6%), nitrofurontoin (4%) and amikacin (3%). In conclusion, the highest resistance rates to E.coli in children were determined against trimethoprim sulfamethoxazole, ampicillin, ampicillin/sulbactam and amoxicillin-clavunic acid. The lowest resistance rates were determined against amikacin, nitrofrontoin, fosfomycin and carbapenems.", "keywords": [ "Çocukluk çağı, üriner sistem enfeksiyonu, Esherichia coli, antibiyotik, direnç" ] } ], "subjects": [], "subject_names": [], "published_date": "2019-12-23", "published_year": "2019", "received_date": null, "accepted_date": null, "volume": "12", "issue": null, "page_first": "92", "page_last": "95", "article_number": null, "conference": { "short_name": "ISAS WINTER-2019 (HSS)", "full_title": "4th International Symposium on Innovative Approaches in Health and Sports Sciences", "name": "4th International Symposium on Innovative Approaches in Health and Sports Sciences", "acronym": "ISAS WINTER-2019 (HSS)", "location": "Samsun, Türkiye", "start_date": "2019-11-22", "end_date": null, "public_id": "76ee0eb0-7f71-420c-9d1c-2b81a3a76e96" }, "proceedings": { "title": "4th International Symposium on Innovative Approaches in Health and Sports Sciences", "series_title": "SETSCI Conference Proceedings", "publisher": "SET Technology", "isbn": "978-605-81988-9-0", "eisbn": null, "issn": null, "eissn": "2687-5527", "doi": null, "doi_prefix": "10.36287", "slug": "setsci-volume-12-2019-legacy-87", "public_id": "083b6600-6489-43ad-9a7d-d9fd7505e910", "url": "https://www.set-science.com/p/setsci-volume-12-2019-legacy-87" }, "license": { "name": "CC BY 4.0", "url": "https://creativecommons.org/licenses/by/4.0/", "code": "CC-BY-4.0", "open_access": true }, "copyright": { "holder": "SET Technology", "year": "2019" }, "funding_statement": null, "funders": [], "references": [ { "order": 1, "raw": "1.\tBryce A, Hay AD, Lane IF, Thornton HV, Wootton M, Costelloe C. Global prevalence of antibiotic resistance in paediatric urinary tract infections caused by Escherichia coli and association with routine use of antibiotics in primary care: systematic review and meta-analysis. BMJ. BMJ; 2016 Mar 15;352:i939. \r\n2.\tO'Neill J. Tackling drug-resistant infections globally: final report and recommendations. Rev Antimicrob Resist. 2016. 2017. \r\n3.\tConway PH, Cnaan A, Zaoutis T, Henry, BV, Grundmeier RW, Keren R. Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials. JAMA. American Medical Association (AMA); 2007 Jul 11;298(2):179–86. \r\n4.\tPrice E, Pallett A, Gilbert RD, Williams C. Microbiological aspects of the UK National Institute for Health and Clinical Excellence (NICE) guidance on urinary tract infection in children. J Antimicrob Chemother. 2010 May;65(5):836–41. \r\n5.\tECDC. 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", "doi": null, "title": null, "authors": null, "source": null, "year": null, "volume": null, "pages": null } ], "statements": { "acknowledgements": null, "conflict_of_interest": null, "data_availability": null, "ai_disclosure": null }, "credit": [], "history": { "published": "2019-12-23" } }