{ "article_id": 1402, "public_id": "df7faf94-f0f9-49ff-926f-723f5304e887", "internal_identifier": null, "source_identifier": "87:61", "status": "published", "type": "research_article", "title": "Hepatitis B virus seroprevalence, associated factors and vaccination status among children and adolescents in Black Sea Region of Turkey", "title_secondary": null, "abstract": "The aim of this study was to determine the prevalence of hepatitis B virus (HBV) serologic markers in children and adolescents and the impact of the vaccination program over the last 9 years. The laboratory records of 10175 children were retrospectively evaluated in children who visited a tertiary hospital, between January 2009 and December 2017. The overall prevalence of HBsAg and anti-HBs were 2.0%, and 69.3%, respectively. HBsAg prevalence increased with age. The carriage rate was more prevalent  in rural areas and in cases born before the country-wide vaccination program. HBeAg positive cases were more common than anti-HBe Ag positive cases (67.6% vs. 32.4%). Anti-HBs was on a rising trend in the 1-23-month age group while it tended to decline after 2-6 years’ age group. There was a decrease in the prevalence of HBsAg in children due to ongoing vaccination efforts but the prevalence of HBsAg was still high during adolescence. The rates of anti-HBs positivity were lower in those living in rural areas and those born before the vaccination program.  Anti-HBs rates were decreasing as age progressed, but this decline was probably due to a natural reduction in anti-HBs concentration in successfully vaccinated individuals.  ", "language": "en", "english_title": null, "english_abstract": null, "doi": "10.36287/setsci.4.9.061", "doi_url": "https://doi.org/10.36287/setsci.4.9.061", "resource_url": "https://www.set-science.com/a/df7faf94-f0f9-49ff-926f-723f5304e887", "pdf_url": "https://www.set-science.com/a/df7faf94-f0f9-49ff-926f-723f5304e887/pdf", "og_image": "https://www.set-science.com/assets/img/og-card-v2.png", "authors": [ { "public_id": "ef32dcc4-928b-464e-a294-78e22542f6c5", "given": "Erhan", "family": "Karaaslan", "full": "Erhan Karaaslan", "literal": null, "orcid": null, "orcid_url": null, "email": "drekaraaslan@gmail.com", "corresponding": true, "sequence": "first", "affiliations": [ { "name": "Tokat Gaziosmanpaşa University", "department": null, "country": null, "country_code": null, "ror": null, "ror_url": null } ] }, { "public_id": "56388759-43ff-4a4c-9bd0-a9886194bcf2", "given": "Meryem", "family": "Çetin", "full": "Meryem Çetin", "literal": null, "orcid": null, "orcid_url": null, "email": "meryemcetin55@yahoo.com", "corresponding": false, "sequence": "additional", "affiliations": [ { "name": "Tokat Gaziosmanpaşa University", "department": null, "country": null, "country_code": null, "ror": null, "ror_url": null } ] } ], "keywords": [ "Hepatitis B, epidemiology, children, vaccination, Turkey" ], "translations": [ { "language": "en", "title": "Hepatitis B virus seroprevalence, associated factors and vaccination status among children and adolescents in Black Sea Region of Turkey", "abstract": "The aim of this study was to determine the prevalence of hepatitis B virus (HBV) serologic markers in children and adolescents and the impact of the vaccination program over the last 9 years. The laboratory records of 10175 children were retrospectively evaluated in children who visited a tertiary hospital, between January 2009 and December 2017. The overall prevalence of HBsAg and anti-HBs were 2.0%, and 69.3%, respectively. HBsAg prevalence increased with age. The carriage rate was more prevalent  in rural areas and in cases born before the country-wide vaccination program. HBeAg positive cases were more common than anti-HBe Ag positive cases (67.6% vs. 32.4%). Anti-HBs was on a rising trend in the 1-23-month age group while it tended to decline after 2-6 years’ age group. There was a decrease in the prevalence of HBsAg in children due to ongoing vaccination efforts but the prevalence of HBsAg was still high during adolescence. The rates of anti-HBs positivity were lower in those living in rural areas and those born before the vaccination program.  Anti-HBs rates were decreasing as age progressed, but this decline was probably due to a natural reduction in anti-HBs concentration in successfully vaccinated individuals.  ", "keywords": [ "Hepatitis B, epidemiology, children, vaccination, Turkey" ] } ], "subjects": [], "subject_names": [], "published_date": "2019-12-23", "published_year": "2019", "received_date": null, "accepted_date": null, "volume": "12", "issue": null, "page_first": "87", "page_last": "91", "article_number": null, "conference": { "short_name": "ISAS WINTER-2019 (HSS)", "full_title": "4th International Symposium on Innovative Approaches in Health and Sports Sciences", "name": "4th International Symposium on Innovative Approaches in Health and Sports Sciences", "acronym": "ISAS WINTER-2019 (HSS)", "location": "Samsun, Türkiye", "start_date": "2019-11-22", "end_date": null, "public_id": "76ee0eb0-7f71-420c-9d1c-2b81a3a76e96" }, "proceedings": { "title": "4th International Symposium on Innovative Approaches in Health and Sports Sciences", "series_title": "SETSCI Conference Proceedings", "publisher": "SET Technology", "isbn": "978-605-81988-9-0", "eisbn": null, "issn": null, "eissn": "2687-5527", "doi": null, "doi_prefix": "10.36287", "slug": "setsci-volume-12-2019-legacy-87", "public_id": "083b6600-6489-43ad-9a7d-d9fd7505e910", "url": "https://www.set-science.com/p/setsci-volume-12-2019-legacy-87" }, "license": { "name": "CC BY 4.0", "url": "https://creativecommons.org/licenses/by/4.0/", "code": "CC-BY-4.0", "open_access": true }, "copyright": { "holder": "SET Technology", "year": "2019" }, "funding_statement": null, "funders": [], "references": [ { "order": 1, "raw": "1.\tOtt JJ, Stevens GA, Groeger J, Wiersma ST. Global epidemiology of hepatitis B virus infection: New estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine. 2012;30:2212-2219.\r\n2.\tLozano R, Naghavi M, Foreman K et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012;380:2095-2128.\r\n3.\tLiaw Y-F, Chu C-M. Hepatitis B virus infection. The Lancet. 2009;373:582-592.\r\n4.\tTosun S. Türkiye’de Viral Hepatit Epidemiyolojisi Yayınlarının Metanalizi. In: Tabak F, Tosun S, editors. Viral Hepatit 2013. Viral Hepatit Savaşım Derneği Istanbul: Istanbul Medikal Yayıncılık; 2013. p. 21-80.\r\n5.\tErtekin V, Selimoglu MA, Altınkaynak S. Sero-epidemiology of hepatitis B infection in an urban paediatric population in Turkey. Public Health. 2003;117:49-53.\r\n6.\tErden S, Büyüköztürk S, Calangu S, Yilmaz G, Palanduz S, Badur S. A study of serological markers of hepatitis B and C viruses in Istanbul, Turkey. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2003;12:184-188.\r\n7.\tMehmet D, Meliksah E, Serif Y, Gunay S, Tuncer O, Zeynep S. Prevalence of hepatitis B infection in the southeastern region of Turkey: comparison of risk factors for HBV infection in rural and urban areas. Jpn J Infect Dis. 2005;58:15-19.\r\n8.\tHadziyannis SJ. Natural history of chronic hepatitis B in Euro-Mediterranean and African Countries. Journal of Hepatology. 2011;55:183-191.\r\n9.\tAkarca US. Chronic hepatitis B. A guideline to diagnosis, approach, management, and follow-up 2007. Turkish Association for the Study of Liver. Turk J Gastroenterol. 2008;19:207-230.\r\n10.\tDentinger CM, McMahon BJ, Butler JC et al. Persistence of Antibody to Hepatitis B and Protection From Disease Among Alaska Natives Immunized at Birth. The Pediatric Infectious Disease Journal. 2005;24:786-792.", "doi": null, "title": null, "authors": null, "source": null, "year": null, "volume": null, "pages": null } ], "statements": { "acknowledgements": null, "conflict_of_interest": null, "data_availability": null, "ai_disclosure": null }, "credit": [], "history": { "published": "2019-12-23" } }