{
    "article_id": 919,
    "public_id": "e01698b3-5dfa-46f7-8f0d-7322198d1a52",
    "internal_identifier": null,
    "source_identifier": "39:284",
    "status": "published",
    "type": "research_article",
    "title": "Production of 5-FU Drug Loaded Biocomposite Materials : Drug Loading Efficiency and Characterization",
    "title_secondary": null,
    "abstract": "Hydroxyapatite/polymer composites are promising materials for drug delivery applications. Studies focusing on the\r\ndevelopment of such composites are available in recent years, as using these materials as a carrier allows us to overcome the\r\nside affects of toxic drugs used especially in cancer treatments and increase treatment efficiency. In this study, hydroxyapatitechitosan (HAp-CTS) biocomposites are produced in the presence of simulated body fluid (SBF) as a carrier for 5-Fluorouracil\r\n(5-FU). 5-FU, which is widely used for the treatment of colon, rectal, breast, ovary, pancreas, stomach, brain and skin cancer,\r\nis selected as drug. Biocomposite materials are produced by wet precipitation method at pH 7.4 and 37°C implementing\r\nglutaraldehyde (GA) as a cross-linking agent. Drug loading process is performed during the wet precipitation. In order to\r\nobserve the effect of GA amount on drug loading efficiency, composites cross-linked with different amounts of GA are\r\nreleased in deinozed water, HCl and phosphate bufffer solution (PBS). Absorbance value of the solution was obtain by Uv-vis\r\n(Jenway 6305) spectra and calibration curve was evaluated to calculate the drug concentrations. Composites are analyzed by\r\nX-Ray Diffraction (XRD), Thermogravimetric Analyses (TGA), Scanning Electron Microscopy (SEM) and particle size\r\ndistribution to observe morphology and structure. It is concluded that drug loaded HAp-CTS composites have a potential to be\r\nused in drug delivery applications.  ",
    "language": "en",
    "english_title": null,
    "english_abstract": null,
    "doi": null,
    "doi_url": null,
    "resource_url": "https://www.set-science.com/a/e01698b3-5dfa-46f7-8f0d-7322198d1a52",
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    "authors": [
        {
            "public_id": "b25a5395-e846-4633-8f9e-99bee93c1497",
            "given": "Nalan",
            "family": "Erdöl Aydın",
            "full": "Nalan Erdöl Aydın",
            "literal": null,
            "orcid": null,
            "orcid_url": null,
            "email": "erdol@itu.edu.tr",
            "corresponding": true,
            "sequence": "first",
            "affiliations": [
                {
                    "name": "İstanbul Technical University",
                    "department": null,
                    "country": null,
                    "country_code": null,
                    "ror": null,
                    "ror_url": null
                }
            ]
        },
        {
            "public_id": "1cef3ad8-bc42-4a03-ba4b-ab276a4d456d",
            "given": "Ebru",
            "family": "Kahraman",
            "full": "Ebru Kahraman",
            "literal": null,
            "orcid": null,
            "orcid_url": null,
            "email": "erdol@itu.edu.tr",
            "corresponding": false,
            "sequence": "additional",
            "affiliations": [
                {
                    "name": "İstanbul Technical University",
                    "department": null,
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                    "country_code": null,
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                    "ror_url": null
                }
            ]
        },
        {
            "public_id": "b03e0a07-e84f-44cd-a8d6-259620a8f2eb",
            "given": "Gülhayat",
            "family": "Nasün Saygılı",
            "full": "Gülhayat Nasün Saygılı",
            "literal": null,
            "orcid": null,
            "orcid_url": null,
            "email": "erdol@itu.edu.tr",
            "corresponding": false,
            "sequence": "additional",
            "affiliations": [
                {
                    "name": "İstanbul Technical University",
                    "department": null,
                    "country": null,
                    "country_code": null,
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                }
            ]
        }
    ],
    "keywords": [
        "Biocomposite material, hydroxyapatite, chitosan, polymer, drug loading"
    ],
    "translations": [
        {
            "language": "en",
            "title": "Production of 5-FU Drug Loaded Biocomposite Materials : Drug Loading Efficiency and Characterization",
            "abstract": "Hydroxyapatite/polymer composites are promising materials for drug delivery applications. Studies focusing on the\r\ndevelopment of such composites are available in recent years, as using these materials as a carrier allows us to overcome the\r\nside affects of toxic drugs used especially in cancer treatments and increase treatment efficiency. In this study, hydroxyapatitechitosan (HAp-CTS) biocomposites are produced in the presence of simulated body fluid (SBF) as a carrier for 5-Fluorouracil\r\n(5-FU). 5-FU, which is widely used for the treatment of colon, rectal, breast, ovary, pancreas, stomach, brain and skin cancer,\r\nis selected as drug. Biocomposite materials are produced by wet precipitation method at pH 7.4 and 37°C implementing\r\nglutaraldehyde (GA) as a cross-linking agent. Drug loading process is performed during the wet precipitation. In order to\r\nobserve the effect of GA amount on drug loading efficiency, composites cross-linked with different amounts of GA are\r\nreleased in deinozed water, HCl and phosphate bufffer solution (PBS). Absorbance value of the solution was obtain by Uv-vis\r\n(Jenway 6305) spectra and calibration curve was evaluated to calculate the drug concentrations. Composites are analyzed by\r\nX-Ray Diffraction (XRD), Thermogravimetric Analyses (TGA), Scanning Electron Microscopy (SEM) and particle size\r\ndistribution to observe morphology and structure. It is concluded that drug loaded HAp-CTS composites have a potential to be\r\nused in drug delivery applications.  \r\n",
            "keywords": [
                "Biocomposite material, hydroxyapatite, chitosan, polymer, drug loading"
            ]
        }
    ],
    "subjects": [],
    "subject_names": [],
    "published_date": "2018-12-31",
    "published_year": "2018",
    "received_date": null,
    "accepted_date": null,
    "volume": "3",
    "issue": null,
    "page_first": "1499",
    "page_last": "1502",
    "article_number": null,
    "conference": {
        "short_name": "ISAS2018-Winter",
        "full_title": "2nd International Symposium on Innovative Approaches in Scientific Studies",
        "name": "2nd International Symposium on Innovative Approaches in Scientific Studies",
        "acronym": "ISAS2018-Winter",
        "location": "Samsun, Türkiye",
        "start_date": "2018-11-30",
        "end_date": null,
        "public_id": "b8a703cc-09f7-4d5b-ae60-eb31a1050720"
    },
    "proceedings": {
        "title": "2nd International Symposium on Innovative Approaches in Scientific Studies",
        "series_title": "Setsci conference indexing system",
        "publisher": "SET Technology",
        "isbn": null,
        "eisbn": null,
        "issn": "2618-6446",
        "eissn": null,
        "doi": null,
        "doi_prefix": null,
        "slug": "setsci-volume-3-2018-legacy-39",
        "public_id": "641f522e-9cf0-4c89-be17-c6037f3d1bca",
        "url": "https://www.set-science.com/p/setsci-volume-3-2018-legacy-39"
    },
    "license": {
        "name": "CC BY 4.0",
        "url": "https://creativecommons.org/licenses/by/4.0/",
        "code": "CC-BY-4.0",
        "open_access": true
    },
    "copyright": {
        "holder": "SET Technology",
        "year": "2018"
    },
    "funding_statement": null,
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        "published": "2018-12-31"
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}