INVESTIGATION OF HYDRATES AND HEMIACETALS FORMS OF QUINOLINEQUINONE DERIVATIVES BY NMR SPECTROSCOPY Raşit Çalışkan1* 1Süleyman Demirel University Department of Chemistry , Isparta, Turkey
IEEE R. Çalışkan, "INVESTIGATION OF HYDRATES AND HEMIACETALS FORMS OF QUINOLINEQUINONE DERIVATIVES BY NMR SPECTROSCOPY", SETSCI Conference Proceedings, vol. 2, pp. 92-92, 2018.
BibTeX
@INPROCEEDINGS{citation,
author = {Çalışkan, Raşit},
title = {INVESTIGATION OF HYDRATES AND HEMIACETALS FORMS OF QUINOLINEQUINONE DERIVATIVES BY NMR SPECTROSCOPY},
year = {2018},
volume = {2},
pages = {92-92},
publisher = {SETSCI Conference Proceedings},
abstract = {Reversible hydration and hemiacetal formation in alcohol of aldehydes and ketones are the simplest addition reactions to carbonyl group and it is one of the basic research subjects in organic chemistry.1 On the other hand, quinoline skeletons are available widespread in nature (such as antidesmone and Lavendamycin) and exhibit antitumor, antimalarial, antimicrobial and anti-inflammatory biologic activities. Moreover, it is already known that hydration plays an important role in the solubility and stability of drugs.2 The equilibrium of between hydrates and hemiacetals of heteroaromatic quinones derivatives were investigated, in aqueous and alcoholic solutions determined by NMR spectroscopy. The formation mechanism of the hydration and hemiacetal forms are discussed. Acknowledgements: The author is indebted to TUBITAK 109T910 (Scientific and Technological Research Council of Turkey) for financial support of this work.},
doi = {},
}
RIS
TY - CONF
AU - Çalışkan, Raşit
TI - INVESTIGATION OF HYDRATES AND HEMIACETALS FORMS OF QUINOLINEQUINONE DERIVATIVES BY NMR SPECTROSCOPY
PY - 2018
PB - SETSCI Conference Proceedings
VL - 2
AB - Reversible hydration and hemiacetal formation in alcohol of aldehydes and ketones are the simplest addition reactions to carbonyl group and it is one of the basic research subjects in organic chemistry.1 On the other hand, quinoline skeletons are available widespread in nature (such as antidesmone and Lavendamycin) and exhibit antitumor, antimalarial, antimicrobial and anti-inflammatory biologic activities. Moreover, it is already known that hydration plays an important role in the solubility and stability of drugs.2 The equilibrium of between hydrates and hemiacetals of heteroaromatic quinones derivatives were investigated, in aqueous and alcoholic solutions determined by NMR spectroscopy. The formation mechanism of the hydration and hemiacetal forms are discussed. Acknowledgements: The author is indebted to TUBITAK 109T910 (Scientific and Technological Research Council of Turkey) for financial support of this work.
DO -
ER -
EndNote
%0 Book
%A Çalışkan, Raşit
%T INVESTIGATION OF HYDRATES AND HEMIACETALS FORMS OF QUINOLINEQUINONE DERIVATIVES BY NMR SPECTROSCOPY
%D 2018
%I {SETSCI Conference Proceedings}
%J {SETSCI Conference Proceedings}
%V 2
%P 92-92
%D 2018
%M doi:
Open Access
INVESTIGATION OF HYDRATES AND HEMIACETALS FORMS OF QUINOLINEQUINONE DERIVATIVES BY NMR SPECTROSCOPY
Raşit Çalışkan1* 1Süleyman Demirel University Department of Chemistry , Isparta, Turkey * Corresponding author: rasitcaliskan@sdu.edu.tr
Reversible hydration and hemiacetal formation in alcohol of aldehydes and ketones are the simplest addition reactions to carbonyl group and it is one of the basic research subjects in organic chemistry.1 On the other hand, quinoline skeletons are available widespread in nature (such as antidesmone and Lavendamycin) and exhibit antitumor, antimalarial, antimicrobial and anti-inflammatory biologic activities. Moreover, it is already known that hydration plays an important role in the solubility and stability of drugs.2 The equilibrium of between hydrates and hemiacetals of heteroaromatic quinones derivatives were investigated, in aqueous and alcoholic solutions determined by NMR spectroscopy. The formation mechanism of the hydration and hemiacetal forms are discussed. Acknowledgements: The author is indebted to TUBITAK 109T910 (Scientific and Technological Research Council of Turkey) for financial support of this work.
Keywords - Quinoline, Hydration, Hemiacetal
[1] a) Greenziad, P.; Luz, Z.; Samuel, D. J. Am. Chem. Soc. 1967, 89, 749-756. b) Bell, R. P. Advan. Phys. Org. Chem. 1966, 4,1-29.
[2] a) Prajapati, S. M.; Patel, K. D.; Vekariya, R-H. S.; Panchala, S. N.; Patel, H. D. RSC Adv. 2014, 4, 24463-24476
b) Spink, E.; Hewage, C.; Malthouse, J. P. Biochemistry, 2007, 46, 12868-12874. c) Huang, S.; Miller, A. K.; Wu, W. Tetrahedron Lett. 2009, 50, 6584-6585. d) Khankari, R. K.; Grant, W. D. J. Thermochim. Acta. 1995, 248, 61-79
This is an Open Access article distributed under the terms of the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
