Synthesis of Drug Microparticle with Hydrophilic Carrier and Its Characterization

In the present study, a model drug, with its low permeable and low aqueous soluble properties, was selected to produce microparticles using an anti-solvent precipitation technique with two different drugs: polymer (0.5, 1.0, w/v %) ratios. The characterization tests were performed using SEM, EDAX, FTIR, and TGA analyses. SEM results showed that a second drug: polymer ratio obtained homogenous surface morphology and the spherical microparticles with 2µm particle size. According to the TGA results, the hydrophilic carrier, bulk drug, and physical mixture were stable up to 200 ∘C, and then the decomposition started. The decomposition behavior of bulk drug and physical mixture showed a similar tendency, whereas the solid dispersion system, a chemical process, showed differences during its decomposition. FTIR results of solid dispersion of model drug had a broadened peak at 3250 cm-1, and the peak intensity at 1750 cm-1 decreased to compare the FTIR spectrum of hydrophilic carrier. FTIR spectra of bulk drug and physical mixture, a physical process, showed similar peaks except for the peak at 1250 cm-1 being in the physical mixture.