MS ve Hematopoetik Kök Hücre Fizyoterapisi

MS ve Hematopoetik Kök Hücre Fizyoterapisi   ErcanTural1*+, Şengül Tural 2 and Şirin Çetin 3 1Ondokuz Mayıs Üniversitesi Sağlık Bilimleri Fakültesi Fizyoterapi ve Rehabilitasyon Bölümü, Samsun 2 Ondokuz Mayıs Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı,Samsun 3Tokat Gaziosman Paşa Üniversitesi Tıp Fakültesi Biyoistatistik Anabilim Dalı,Tokat *Corresponding author: ercant@omu.edu.tr +Speaker: ercant@omu.edu.tr Tam metin     Abstract –1990’larda ortaya çıkan bir tedavi şekli olan hematopoetik kök hücre transplantasyonu (HKHT), yoğun kemoterapi ile birlikte hastanın kendinden alınan otolog veya başka bir vericiden elde edilen kök hücreler ile yapılan allojenik HSCT uygulamaları biçiminde yapılmaktadır. Kök hücrelerin başka hücrelere dönüşebiliyor olması bu alanda çalışan araştırmacıların dikkatini çekmiştir. Aynı zamanda kök hücrelerin bol miktarda bulunmaları, birçok hücre tipine farklılaşarak çoğalabilmeleri ve alıcılara güvenli ve etkin bir şekilde nakledilebilmelerinden dolayı çeşitli hastalıkların tedavisinde tercih edilmektedir. Multiple Skleroz (MS), merkezi sinir sisteminde myelin hasarına ya da kaybına yol açan kronik inflamatuar bir hastalıktır. MS’in en önemli semptomları motor, duysal, görsel ve kognitif fonksiyonlardaki yetersizliktir. MS’de kök hücre transferi öncesi ve sonrasında görülebilecek nöromüsküler ve fonksiyonel komplikasyonların azaltılması ve yaşam kalitesinin artırılması için hastaya göre iyi planlanmış Fizyoterapi ve Rehabilitasyona programına ihtiyaç duyulur. Literatür incelendiğinde Dünya da ve Ülkemizde MS’de hematopoetik kök hücre transferi (HKHT)’ne yönelik geliştirilmiş bir Fizyoterapi ve Rehabilitasyon protokolünün olmadığı görülmüştür. Araştırmamızda literatür incelenerek HKHT öncesi ve sonrası MS’de görülen yaygın komplikasyonların erken değerlendirilmesi ve fonksiyonel kaybın en aza indirilerek iyileşmenin ve yaşam kalitesinin artırılmasına yönelik yapılmış Fizyoterapi ve Rehabilitasyon çalışmalarının derlenmesi amaçlanmıştır.   Keywords – : Fizyoterapi, multipl skleroz, kök hücre, rehabilitasyon       Abstract Hematopoietic stem cell transplantation (HSCT), a form of treatment that emerged in the 1990s, is performed in the form of allogeneic HSCT with intensive chemotherapy with stem cells obtained from the patient's autologous or other donor. The ability of stem cells to transform into other cells has attracted the attention of researchers working in this field. It is also preferred in the treatment of various diseases because of the abundance of stem cells, the ability to differentiate and proliferate into many cell types and the safe and efficient transport to recipients. Multiple Sclerosis (MS) is a chronic inflammatory disease that causes damage or loss of myelin in the central nervous system. The most important symptoms of MS are insufficiency in motor, sensory, visual and cognitive functions. In MS, a well-planned physiotherapy and rehabilitation program is needed to reduce the neuromuscular and functional complications that may occur before and after stem cell transfer and to improve the quality of life. When the literature is examined, it is seen that there is no developed physiotherapy and rehabilitation protocol for hematopoietic stem cell transfer (HSCT) in MS and in the world. The aim of this study was to evaluate the early complications of MS before and after HSCT and to review the physiotherapy and rehabilitation studies aimed at minimizing functional loss and improving quality of life.   Keywords; Physiotherapy, multipl sclerosis, stem cell, rehabilitation

MS and Hematopoietic Stem Cell Physiotherapy ErcanTural1*+, Şengül Tural 2 and Şirin Çetin 3 1Ondokuz Mayıs University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Samsun 2 Ondokuz Mayıs University, Faculty of Medicine, Department of Medical Biology, Samsun 3Tokat Gaziosman Paşa University, Faculty of Medicine, Department of Biostatistics, Tokat *Corresponding author: ercant@omu.edu.tr +Speaker: ercant@omu.edu.tr Full text Abstract –Hematopoietic stem cell transplantation (HSCT), a treatment method that emerged in the 1990s, is performed in the form of allogeneic HSCT applications using autologous stem cells taken from the patient or stem cells obtained from another donor, in combination with intensive chemotherapy. The ability of stem cells to differentiate into other cells has attracted the attention of researchers working in this field. Stem cells are also preferred in the treatment of various diseases because of their abundance, ability to differentiate into many cell types and proliferate, and safe and effective transplantation to recipients. Multiple Sclerosis (MS) is a chronic inflammatory disease that causes myelin damage or loss in the central nervous system. The most important symptoms of MS are impairments in motor, sensory, visual, and cognitive functions. In MS, a well-planned physiotherapy and rehabilitation program tailored to the patient is needed to reduce neuromuscular and functional complications that may occur before and after stem cell transfer and to improve quality of life. A review of the literature reveals that there is no developed physiotherapy and rehabilitation protocol for hematopoietic stem cell transfer (HSCT) in MS, either globally or in our country. In our research, we aimed to compile physiotherapy and rehabilitation studies that have been conducted to assess common complications seen in MS before and after HSCT early, to minimize functional loss, and to improve recovery and quality of life, by reviewing the literature. Keywords – : Physiotherapy, multiple sclerosis, stem cell, rehabilitation Abstract Hematopoietic stem cell transplantation (HSCT), a form of treatment that emerged in the 1990s, is performed in the form of allogeneic HSCT with intensive chemotherapy with stem cells obtained from the patient's autologous or other donor. The ability of stem cells to transform into other cells has attracted the attention of researchers working in this field. It is also preferred in the treatment of various diseases because of the abundance of stem cells, the ability to differentiate and proliferate into many cell types and the safe and efficient transport to recipients. Multiple Sclerosis (MS) is a chronic inflammatory disease that causes damage or loss of myelin in the central nervous system. The most important symptoms of MS are insufficiency in motor, sensory, visual and cognitive functions. In MS, a well-planned physiotherapy and rehabilitation program is needed to reduce the neuromuscular and functional complications that may occur before and after stem cell transfer and to improve the quality of life. When the literature is examined, it is seen that there is no developed physiotherapy and rehabilitation protocol for hematopoietic stem cell transfer (HSCT) in MS and in the world. The aim of this study was to evaluate the early complications of MS before and after HSCT and to review the physiotherapy and rehabilitation studies aimed at minimizing functional loss and improving quality of life. Keywords; Physiotherapy, multiple sclerosis, stem cell, rehabilitation